Enhancing Antioxidant, Antimicrobial And Anti-Nsclc Activities Of (-)-Epigallocatechin Gallate Encapsulated Poly(Butyl-2-Cyanoacrylate) Nanowires Applications In Dietary Supplements

(-)-Epigallocatechin gallate (EGCG) exhibits multiple biological activities, but unfortunately with poor stability. Poly(butyl-2-cyanoacrylate) (PBCA) nanoparticles have been widely elaborated for nearly 50 years. However, PBCA-based nanowires (PNWs) were reported scarcely. Here, EGCG-encapsulated PNWs (EGCG@PNWs) were successfully constructed. Employing PNWs as a delivery material, 2.0 mg EGCG into oil phase as optimum allocation was encapsulated in PNWs, forming EGCG@PNWs with the particle sizes of about 200 nm in diameter and 4 mu m in length, encapsulation efficiency of about 93.96 +/- 3.01%, and the zeta potential more than -30 mV. Further, the slower EGCG release from EGCG@PNWs (Oil) in 95% ethanol fatty simulant exhibited higher antioxidant activity than that of 50% ethanol. The antibacterial activities against E. coli and S. aureus and the growth inhibition effects on non-small-cell lung cancer (NSCLC) were also enhanced. Results revealed that EGCG@PNWs can be used as dietary supplements to enhance antioxidant, antibacterial and anti-NSCLC effects.