Effects of bacterial cellulose on glucose metabolism in an in vitro chyme model and its rheological evaluation

Hyperglycaemia affects the health of people worldwide. The study investigated the effects of bacterial cellulose (BC) on glucose metabolism using an in vitro chyme model, including glucose adsorption, glucose diffusion, kinetics model of glucose and rheological properties of BC. The results indicated that BC exhibited significant inhibition of alpha-amylase in a dose-dependent manner (IC50 = 7.86 mg mL(-1)) and could significantly adsorb glucose by binding to the glucose molecules (4.11 +/- 0.18 mmol g(-1)) (P < 0.05). The BC chyme system was a non-Newtonian fluid showing shear thinning and has the characteristics of elastic solid. The diffusion behaviour of glucose in the BC chyme system conformed to first-order release kinetics model, indicating its inhibition of glucose diffusion by changing the rheological properties of chyme. This study provides a theoretical basis for dietary intervention and nutritional support for patients with hyperglycaemia.