A Multi-Analyte Liquid Biopsy Assay Integrating Cfdna Methylation And Protein Biomarkers For Liver Cancer Diagnosis

Liver cancer is the third leading cause of cancer-related death worldwide and nearly half of deaths occur in China. The major histological types are hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC). Serum marker alpha-fetoprotein (AFP) and ultrasound have been widely used in liver cancer high-risk population surveillance programs, but both methods have unsatisfactory sensitivities for early stage of the disease and sub-optimal specificities. AFP also has much lower sensitivity for ICC compared to HCC.