Correlation Between Osteocalcin And Visceral Fat Area In Overweight And Obese Male Population

Objective: To investigate the correlation between serum level of osteocalcin (OC) and visceral fat area (VFA) in overweight and obese male subjects. Methods: A total of 70 men aged from 35 to 75 (mean 52.13+/-7.21) years were enrolled during January 2015 to December 2016, which were divided into control group (n=26), overweight group (n=20) and obese group (n=24) according to body mass index (BMI). Metabolic parameters, including waist circumference (WC), fasting insulin (FINS), fasting blood glucose (FBG), insulin resistance index, triglyceride (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), and serum levels of OC, C reactive protein (CRP), adiponectin (APN) and visceral fat area (VFA), were evaluated before and after the treatment and the differences between groups were compared. The insulin resistance index was estimated by homeostasis model assessment of insulin resistance (HOMA-IR) while visceral fat area (VFA) was quantified via magnetic resonance imaging. Results: OC had a decreasing trend in the control group (11.45+/-2.51 mu g/L) and overweight group (6.73+/-2.31 mu g/L) and obese group (4.25+/-1.29 mu g/L) (P<0.01); among all the overweight and obese subjects, WC, HOMA-IR and VFA were independent factors of OC (P<0.01). Conclusion: With different levels of visceral fat content, the variation of OC in overweight and obese male subjects was closely related to VFA, indicating that OC might participate in the development of abdominal obesity.