Conjugation Of Curcumin With Ag Nanoparticle For Improving Its Bioavailability And Study Of The Bioimaging Response

We report here the production of curcumin conjugated polyvinylpyrrolidone (PVP)-capped Ag nanoparticles for potential biological applications. Evidence for the efficient conjugation of hydrophobic curcumin to the synthesized nanoparticles (NPs) is expected from UV-Vis, zeta potential and Fourier transform infrared (FT-IR) analysis. Curcumin conjugated to PVP-capped Ag NPs is observed to gain high water solubility and bioavailability in a biological environment without diminishing its therapeutic properties. The presence of the main therapeutic group, the diarylheptanoid chromophore of curcumin, indicates the existence of its medicinal behavior in the curcumin-Ag NPs complex. Moreover, the fluorescence efficiency of PVP capped Ag NPs in the breast cancer cellular medium have been found to be significantly enhanced (by factor of similar to 2.37) with curcumin conjugation. The production of bioavailable curcumin provides an opportunity to expand the clinical repertoire of this efficacious agent without hampering the environment and human health.