Kilogram-Scale GMP Manufacture of Tirzepatide Using a Hybrid SPPS/LPPS Approach with Continuous Manufacturing
Michael O. Frederick, Raymond A. Boyse,Timothy M. Braden,Joel R. Calvin,Bradley M. Campbell,Shujauddin M. Changi, Stephanie R. Coffin, Carmel Condon,Olivia Gowran,Jennifer McClary Groh,Stephen R. Groskreutz,Zachary D. Harms, Ashley A. Humenik,Neil J. Kallman, Nicholas D. Klitzing,Michael E. Kopach,Juliana K. Kretsinger,Gordon R. Lambertus, Jeffrey T. Lampert, Laura M. Maguire,Humphrey A. Moynihan, Nessa S. Mullane,John D. Murphy, Marie E. O'Mahony,Rachel N. Richey,Kevin D. Seibert,Richard D. Spencer,Mark A. Strege,Nil Tandogan, Torres,Sergey Tsukanov,Han Xia Organic Process Research & Development（2021）
Key words
tirzepatide,hybrid SPPS/LPPS synthesis,synthetic peptide,nanofiltration
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