Development Of Pegylated Rosmarinic Acid Liposome For Anti-Cancer And Anti-Oxidant Effect

Apple mint (Mentha suaveolens) has been widely used in traditional herbal medicine since it shows hypotensive, analgesic, and anti-inflammatory effects. The active ingredient of apple mint is rosmarinic acid (RA), an ester of caffeic acid and 3,4-dihydroxyphenyl lactic acid. RA has many pharmacological effects, such as anti-oxidative, anti-apoptotic, anti-tumorigenic, and anti-inflammatory properties. In this study, RA is incorporated in PEGylated liposomes to enhance its pharmacological effects. The physical characteristics of RA liposomes were demonstrated by dynamic light scattering, zeta potential, and field emission scanning electron microscopy. The anti-oxidation and anti-cancer effects of RA liposomes were evaluated in HT22 and MDA-MB-231 cell lines, respectively.