Novel treatment strategy of targeting epigenetic dysregulation in pancreatic neuroendocrine tumors
ANNALS OF SURGICAL ONCOLOGY(2023)
摘要
Epigenetic dysregulation with DNA methyltransferase 1 is associated with pancreatic neuroendocrine tumors and is a potential targetable strategy. 5-azacytidine and chemotherapy in combination can reduce cell proliferation, upregulate silenced tumor suppressor genes, and decrease in vivo tumors in pancreatic neuroendocrine tumors.
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关键词
pancreatic neuroendocrine tumors,epigenetic dysregulation,neuroendocrine tumors
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