Proapoptotic Effect Of Ginkgo Biloba Extract On U87 Glioma Cells

Objective To study the pro-apoptotic effect of Ginkgo biloba extract on U87 glioma cells. Methods After 24 hours of Ginkgo biloba extract intervention, the proliferation of U87 glioma cells was observed by CCK-8 with different concentrations of Ginkgo biloba extract at 100, 150, 200 and 250mg/L. The effect of Ginkgo biloba extract on apoptosis of U87 glioma cells was analyzed by flow cytometry. AnnexinV-FITC and PI double staining were used to detect the effect of Ginkgo biloba extract on apoptosis of U87 glioma cells. Results Ginkgo biloba extract could inhibit the proliferation of U87 glioma cells in a concentration-dependent manner. After 24 hours of Ginkgo biloba extract intervention, flow cytometry showed that the apoptosis rate of U87 glioma cells increased significantly with the increase of Ginkgo biloba extract concentration. Conclusion Ginkgo biloba extract can induce apoptosis of U87 glioma cells.