The Roles of Oxidative Stress in Regulating Autophagy in Methylmercury-induced Neurotoxicity

Yanfeng Wei,Linlin Ni,Jingjing Pan,Xiaoyang Li,Bin Xu,Yu Deng,Tianyao Yang,Wei Liu

Neuroscience（2021）

引用 8|浏览3

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摘要

•Oxidative stress is one of the important mechanisms of MeHg-induced neurotoxicity.•Autophagy is one of the important processes of MeHg-induced neurotoxicity.•Oxidative stress plays a certain regulatory role on autophagy.•ROS and Nrf2 regulated mTOR-dependent/independent autophagy in MeHg neurotoxicity.

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关键词

3-MA,6-OHDA,Akt,ALS,AMPK,AREs/EpREs,AS,ASK,BBB,Bcl-2,Bnip3,CaMKKβ,CAT,Cd,CsA,Cyt c,DMCMP,EGCG,ERK,FIP 200,FOXO,GCL,Gclc,GCs,GFP,GR,GSH,GSH-Px,GSK3β,GST,Gsta4,GSTs,HDACi,HMGB1,hNPCs,HO-1,IKKβ,JNK,Keap1,KIR,LC3,LIR,LKB1,MAPKs,MDA,MeHg,Mn,MOMP,MPT,MSCs,mTOR,NDP52,Neh6,NiO-NPs,NQO-1,Nrf2,NSCs,NUPR1,•OH,O2•−,p70s6k,Pb,PbNO3,PC12,PI3K,RagD,Rbx1,Rheb,ROS,rPT,RPTOR,Sb,Sesn,SGK1,SH,sMaf,SOD,SQSTM 1,TEM,TSC,UBA,ULK1,Vps34,xCT,β-TRCP,Ψm

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