Local co-delivery of 5-fluorouracil and curcumin using Schiff's base cross-linked injectable hydrogels for colorectal cancer combination therapy

•The combination of 5-FU and curcumin is more effective against colon cancer.•The drug delivery systems can provide enhanced therapeutic efficacy.•Using micelle/hydrogel system for the simultaneous administration of two drugs.•Simultaneous sustained release of 5-FU and Curcumin from injectable hydrogel.