Hesperidin in orange juice improves human endothelial function in subjects with elevated blood pressure and stage 1 hypertension: A randomized, controlled trial (Citrus study)

•Hesperidin enriched orange juice improves human endothelial function.•Endothelial function improves both at postprandial and after sustained intake.•Endothelial function improvement was directly linked to hesperidin content of drinks.•Hesperidin enriched orange juice improves inflammatory status.•Hesperidin enriched orange juice induces beneficial changes at transcriptomic level.