Dysregulated expression of miR-642a-5p and its target receptor-interacting serine/threonine-protein kinase 1 contribute to the phycocyanin-mediated inhibitory function on non-small cell lung cancer

Shuai Hao,Qi Yang,Fannian Li,Qiancheng Li,Yuanpu Liu,Shuang Li,Lei Zhao,Chengtao Wang

Journal of Functional Foods（2021）

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摘要

•miRNA variations were screened through high-throughput miRNA-seq.•miR-642a-5p was significantly increased by phycocyanin in NSCLC cells.•RIPK1 was a direct target of miR-642a-5p in NSCLC cells.•Phycocyanin inhibits NSCLC cell activities through miR-642a-5p/RIPK1/NF-κB axis.

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关键词

Cell activity,miR-642a-5p,Non-small cell lung cancer,Phycocyanin,Receptor-interacting serine/threonine-protein kinase 1

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