Modular Total Synthesis Of (-)-Palmyrolide A And (+)-(5s,7s)-Palmyrolide A Via Ring-Closing Metathesis And Alkene Isomerization Dagger

Main observation and conclusionA pentamodule assembly approach has been established for total synthesis of the naturally occurring (-)-palmyrolide A and (+)-5,7-epi-palmyrolide A. By using the racemic tert-butyl carbinol-containing alkyl iodide, the two diastereoisomeric macrolides could be obtained from the same sequence of reactions, demonstrating the flexibility of the multimodule assembly strategy for diverted total synthesis.