Improved resolution of phenotypic subsets in human T-ALL by incorporation of RNA-seq based developmental profiling

Rachel Wong, Andrew Nguyen,Xuehai Wang,Lauren Chong,Kateryna Tyshchenko,Scott D. Brown,Rob A. Holt,Christian Steidl,Andrew P. Weng

Leukemia Research（2021）

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摘要

•Thymic differentiation signatures organize leukemia along a developmental track.•The use of differentiation signatures improves upon current classification methods.•Improved disease classification may identify therapy-resistant leukemia.

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