Fatigue and activity-dependent conduction block in neuromuscular disorders

Atsuko Tsuneyama,Kazumoto Shibuya,Sonoko Misawa,Yo-Ichi Suzuki,Tomoki Suichi,Yuta Kojima,Keigo Nakamura,Hiroki Kano,Mario J Prado,Satoshi Kuwabara

JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM（2022）

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摘要

•Demyelination and increased axonal branching reduce the safety factor for impulse transmission.•Axonal hyperpolarization induced by voluntary contraction result in conduction block, and thereby fatigue in CIDP/SBMA patients.•Activity-dependent conduction block causes peripheral fatigue in neuromuscular diseases.

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关键词

Fatigue,Chronic inflammatory demyelinating polyneuropathy,Spinal and bulbar muscular atrophy,Activity-dependent hyperpolarization and conduction block

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