Overall lack of genotoxic activity among five common low- and no-calorie sweeteners: A contemporary review of the collective evidence

•The safety of low- and no- calorie sweeteners is frequently revisited.•Genotoxicity potential of five common LNCS was surveyed and summarized.•Peer-review literature and HTS data were integrated with authoritative assessments.•Emphasis was placed on assays most frequently considered for hazard identification.•Findings support authoritative conclusions regarding lack of genotoxic potential.