Synthesis Of 2,6-Dimethylbenzamide N-(5-Methyl-3-Isoxazolyl) (D2916) Labelled With C-14

E Azim,Jc Maurizis,Jm Dupuy, F Lepage, A Veyre,Jc Madelmont

JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS（1997）

引用 0|浏览0

暂无评分

摘要

Carbonation of 2,6-dimethyl phenyl lithium with (CO2)-C-14 afforded 2,6-dimethylbenzoic acid, alpha-C-14 2 which was transformed into 2,6-dimethylbenzoic acid halide, alpha-C-14 3. Subsequent condensation of the latter compound with 3-amino 5-methyl isoxazole afforded 2,6-dimethylbenzamide N-(5-methyl-3-isoxazolyl) (D2916)4 (radiochemical 95% purity) in an overall yield of about 35% based on [C-14] barium carbonate.

查看译文

关键词

2,6-dimethylbenzoic acid, alpha-C-14, 2,6-dimethylbenzoic acid halide, alpha-C-14, 2,6-dimethylbenzamide N-(5-methyl-3-isoxazolyl), (D2916)

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要