Gender, Age And Tp53 Aberrations In Context Of Complex Karyotypes In Chronic Lymphocytic Leukemia Patients In The Era Of Chemo Plus /- Immunotherapy

Chronic lymphocytic leukemia (CLL) is the most common adult leukemia characterized by a heterogeneous course of the disease. Determination of prognosis of patients (pts) is based on clinical and laboratory parameters, where cytogenetic examination plays a significant role. According to recent studies the complex karyotype (CK) shows to have adverse prognostic value and occurrence of CK is reported in 15-20% of untreated pts. Multiple diverse chromosomal translocations, deletions, duplications, numerical changes or dicentric chromosomes arise within complex karyotypes.