Metabolomic Study Of Normal And Modified Nucleosides In The Urine Of Mice With Lipopolysaccharide-Induced Sepsis By Lc-Ms/Ms

Endogenous normal and modified nucleosides have been studied as potential biomarkers of various inflammatory diseases including sepsis. However, no systematic nucleoside profiling and pattern analysis study has been performed in sepsis. In this study, simultaneous liquid chromatography-mass spectrometry profiling of normal and modified nucleosides was performed to characterize altered nucleoside metabolism in sepsis mice.