Frozen-Thawed And Fresh Embryo Mixed Transfer Cycles Provide Better Pregnancy Outcome In Patients Who Experience Repeated Pregnancy Failure

Purpose: This study aims to investigate the outcomes of co-transfer of frozen-thawed and fresh embryos in in vitro fertilization-embryo transfer (IVF-ET) cycles to improve pregnancy outcome in patients who experience repeated pregnancy failure. Materials and Methods: Patients were divided into five groups based on the characteristics and number of embryos transferred. All embryos transferred were on cleavage stage (Day 3). Group A had 42 patients transferred with one fresh cleavage embryo and one frozen-thawed, group B had 84 patients transferred with one fresh cleavage embryo, group C had 84 patients transferred with two fresh cleavage embryos, group D had 84 patients transferred with one frozen-thawed cleavage embryo and group E had 84 patients transferred with two frozen-thawed cleavage embryo. Results: There were no significant differences in demographic characteristics of these groups (P>0.05). However, clinical pregnancy rate, implantation rate, abortion rate, heterotopic pregnancy rate, malformation rate and other indicators were different among these groups (P<0.05). Group A had higher implantation rate and clinical pregnancy rate. Conclusion: Frozen-thawed and fresh embryo mixed transfer provides better outcome for patients who experience repeated pregnancy failure.