The Influence Of The Bone Marrow Niche On Drug Response Phenotypes Of Blood Cancers

Sophie Rabe,Eva Schitter,Tobias Roider,Peter-Martin Bruch,Carolin Kolb,Marta Stolarczyk,Jennifer Huellein,Junyan Lu, Christof Von Kalle,Christoph Lutz,Peter Dreger,Carsten Mueller-Tidow,Thorsten Zenz,Wolfgang Huber,Sascha Dietrich

BLOOD（2018）

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摘要

Background: Signals provided by the microenvironment can modify and circumvent pathway activities that are therapeutically targeted by drugs. However, a systems-level understanding of how the microenvironment and the genetic and molecular alterations of the tumor interact with each other and contribute to drug resistance is lacking.

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