Established Prevention Of Vaso-Occlusive Crises With Crizanlizumab Is Further Improved In Patients Who Follow The Standard Treatment Regimen: Post-Hoc Analysis Of The Phase Ii Sustain Study

Background: In the 52-week SUSTAIN study, which compared the P-selectin inhibitor crizanlizumab with placebo in patients with sickle cell disease (SCD), crizanlizumab 5.0 mg/kg significantly reduced the frequency of vaso-occlusive crises (VOCs) leading to healthcare utilization versus placebo (Ataga KI et al. N Engl J Med 2017;376:429-39). The overall incidences of adverse events and serious adverse events were similar among the patients treated with crizanlizumab and placebo.