Sirt5 As A Therapeutic Target In Acute Myeloid Leukemia

Acute myeloid leukemia (AML) is an aggressive hematopoietic neoplasm with five-year overall survival rates <30% on standard of care therapy. Relapse is common and thought to originate from AML stem cells that survive in the protective bone marrow (BM) microenvironment. Next generation sequencing (NGS) has revealed the somatic mutation spectrum of AML and the approval of midostaurin for FLT3 ITD- and enasidenib for IDH2 -mutated AML is evidence that the molecular knowledge is being translated clinically.