Enyne- And Enediyne-Gamma-Lactones From The Bark Of Meiogyne Cylindrocarpa

The chemical investigation of the EtOAc extract of the bark of Meiogyne cylindrocarpa led to the isolation of two enyne- and five enediyne-gamma-lactones, sapranthins A-G (1-7), of which six were new. They were identified by mass spectrometry, extensive one- and two-dimensional NMR spectroscopy and through comparison with data reported in the literature. Sapranthins B, C and E (2, 3 and 5, respectively) showed a weak cytotoxic activity on L1210 with IC50 values comprised between 8.1 and 18.0 mu M. (C) 2011 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.