Gene Editing Of Btk In Acute Myeloid Leukaemia Using Crispr-Cas9

BLOOD(2018)

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摘要
Acute myeloid leukemia (AML) blood cancer is found primarily in adults and the elderly, being the third biggest blood cancer killer. In the last decades there has been some improved rates in younger patients, but little improvement in older patients. AML survival rates are the worst of all blood cancers, therefore finding new therapeutic targets to treat AML is crucial.
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