Palladium-Catalyzed Alpha-Arylation Of Dimethyl Malonate And Ethyl Cyanoacetate With O-Alkoxybromobenzenes For The Synthesis Of Phenylacetic Acid, Esters And Phenylacetonitriles

alpha-Aryl malonate and alpha-aryl cyano acetate moieties are found in the structures of many bioactive compounds. They are also key intermediates for the synthesis of many compounds such as isoflavonoids. In this work, we synthesized these compounds, with different patterns of substitution, starting with the palladium-catalyzed reaction of o-alkoxybromoarenes with dimethyl malonate or ethyl cyanoacetate. Under the conditions applied, moderate to good yields of arylmalonate monoesters, phenylacetic esters or acids, and benzylnitrile derivatives were obtained.