Free Radical Scavenging And Alpha-Glucosidase Inhibitory Activity Of (E)-Methyl/Ethyl-3-(2-Hydroxyphenyl)Acrylates

(E)-Methyl/ethy1-3-(2-hydroxyphenyl)acrylates 3a-x have been prepared by the reaction of salicylaldehydes 1a-l with Wittig reagents such as methyl (triphenylphosphoranylidene)acetate 2a and ethyl (triphenylphosphoranylidene)acetate 2b in dry DCM at room temperature. All the synthesized compounds have been evaluated for free-radical scavenging and alpha-glucosidase inhibitory activities. Compounds 3c and 3d display DPPH free radical scavenging activity. All the compounds have shown ABTS free radical scavenging activity except four compounds 3s-t and 3w-x. Compounds 3g, 3p and 3r display alpha-glucosidase inhibitory activity.