Lapachol-loaded triblock copoly(oxyalkylene)s micelles: Potential use for anticancer treatment

Karen P.S. Lopes,Daniel P. Pinheiro,João F.C. Neto,Tamara A. Gonçalves,Stefano A. Pereira,Claudia Pessoa,Icaro G.P. Vieira,Maria Elenir N.P. Ribeiro,Stephen G. Yeates, Nágila M.P.S. Ricardo

Journal of Molecular Liquids（2021）

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摘要

•Poor solubility of drugs is one of the adversities faced for its therapeutic use.•Micelles has been showing efficiency to assist in the carrying poorly soluble drugs.•Binary mixtures have a greater ability to increase drug solubility.•Micelles as Lapachol nanocarriers have potential application in cancer treatment.

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关键词

Lapachol solubility and drug release,Mixture copolymers,MTT assay and Brine shrimp

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