Synthesis and Antifungal Activity of 1,3-bis-1,2,3-Triazol-1-yl-Propan-2-ol Based Compounds

Omar Valdez-Arcos,Josué Varela-Palma,Alejandra Ramírez-Villalva,Aydeé Fuentes-Benites,Marco A. García-Eleno,M. V. Basavanag Unnamatla,Erick Cuevas-Yañez

PHARMACEUTICAL CHEMISTRY JOURNAL（2021）

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摘要

small series of 4′-substituted 1,3-bis-1,2,3-triazol-1-yl-propan-2-ol compounds was prepared via CuAAC click reaction of 1,3-diazido-2-propanol and various alkynes R. Antifungal evaluation of these molecules revealed important activity against some yeast strains, and one compound (R = Ph) displayed antifungal activity comparable with that of fluconazole standard.

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关键词

1,2,3-triazole,1,3-diazido-2-propanol,click chemistry,antifungal activity

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