Comparative Studies Of Influence Of Pp Electret Polarities In Skin Structure

The +/- 1000V polypropylene (PP) electrets were prepared by means of corona charging method. The skin structure changes were observed after the application of +/- 1000V PP electrets on rat abdominal skin using inverted phase contrast microscope. The results indicated that both the positive and negative PP electrets could change the microstructure of rat skin. Compared with +1000V PP electret, -1000V PP electret had more effect on disruption of arrangement of lipid layer which could more significantly to reduce the barrier function of skin stratum corneum. Therefore, -1000V electret could be used in transdermal delivery formulation to increase the drug permeation through skin.