Treating Moderate-To-Severe Persistent Allergic Rhinitis By Endoscopic Posterior Nasal Neurectomy: A Study Of Efficacy And Effects On Autophagy

Objective: This study aimed to analyze the efficacy of endoscopic posterior nasal neurectomy (EPNN) in treating patients with moderate-to-severe persistent allergic rhinitis (PAR), and its effects on autophagy. Methods: A total of 63 patients with moderate-to-severe PAR in our hospital from July 2018 to June 2019 were randomized into the Control Group (CG, n=31, conservative medication) and the Surgery Group (SG, n=32, EPNN) by drawing lots. Clinical efficacy was compared between the two groups. Results: (1) At 1 month, 3 months, 6 months and 12 months after treatment, the VAS and QOL (quality of life) scores were significantly lower in the SG (P<0.05) while no intergroup and intragroup significance was found in the length of wetted tear test strip (P>0.05). (2) At 12 months after treatment, the IL-4,IL-13 and IL-17A levels were significantly lower in the SG (P<0.05). (3) According to IHC, the expressions of autophagy-related proteins ECP and LC3 were weakened. Conclusion: In patients with moderate-to-severe PAR, EPNN can mitigate pain intensity, improve QOL and inhibit autophagy.