Suppression Of Gsk3 Beta By Erk Mediates Lipopolysaccharide Induced Cell Migration In Macrophage Through Beta-Catenin Signaling

We investigate the role of beta-catenin signaling in the response of macrophage to lipopolysaccharide (LPS) using RAW264.7 cells. LPS rapidly stimulated cytosolic beta-catenin accumulation. beta-catenin-mediated transcription was showed to be required for LPS induced gene expression and cell migration. Mechanically, ERK activation-primed GSK3 beta inactivation by Akt was demonstrated to mediate the LPS induced beta-catenin accumulation. Overall, our findings suggest that suppression of GSK3 beta by ERK stimulates beta-catenin signaling therefore contributes to LPS induced cell migration in macrophage activation.