Properties Of Triple Helices Formed By Oligonucleotides Containing 8-Amitiopurines

A Avino, M Frieden,Jc Morales,Bg De La Torre,R Guimil-Garcia,M Orozco,C Gonzalez,R Eritja

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS（2003）

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摘要

The synthesis of parallel hairpins carrying 8-aminopurines is described. These hairpins have a high affinity for specific polypyrimidine sequences resulting in the formation of very stable triplexes.

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关键词

oligonucleotides, triplex, 8-aminoadeiline, 8-aminoguanine, 2 '-O-alkyl-RNA

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