Nt-Probnp Is Associated With Age, Gender And Glomerular Filtration Rate In A Community-Dwelling Population

Objective: This study assessed the relationship between N-terminal pro-brain natriuretic peptide (NT-proBNP), age, gender, renal function, and obtained the reference range of NT-proBNP in each subgroup by age and gender in a community-dwelling population. Methods: In total, 1499 subjects ranging from 23 to 96 years were included in the study, NT-proBNP, age, gender, eGFR (Estimated Glomerular Filtration Rate) and other relevant indicators were recorded from 5 years of follow-up research. The relationships between NT-proBNP, age, gender, and eGFR were clarified with scientific research and statistical methods. Results: The median age was 61.4 years old, and the median NT-proBNP level was 37.9 pg/mL (interquartile range, 17.025-74.95 pg/mL). Age was divided into 4 groups by 20 year increments. The plasma NT-proBNP concentrations were significantly positively related to age. Gender subgroup analysis showed that the level of NT-proBNP in the female group was higher than that in the male group, while the difference was not statistically significant when the age was over 80. eGFR was divided into two groups based on the critical value of 60 mL/(min.1.73 m(2)), the plasma NT-proBNP level (median, 167.5; interquartile range, 82.33-371.05 pg/mL) in the lower eGFR group was significantly higher than that (median, 37.85; interquartile range, 17.2-73.88 pg/mL) in the higher eGFR group. Linear correlation analysis showed that NT-proBNP was negatively correlated with eGFR. However, no significant correlation was found when we compared the NT-proBNP with the eGFR decreasing in 5 years. Conclusions: In the community-dwelling population, NT-proBNP increased with age, and was higher in female subjects less than 80 years old. Furthermore, eGFR was negatively correlated with NT-proBNP. Nonetheless, NT-proBNP was not an independent risk factor for kidney function.