Syntheses And Crystal Structures Of (S)-Methyl-2-(4-R-Phenylsulfonamido)-3-(1h-Indol-3-Yl)Propanoate (R = H (1) And Cl (2))

The title compounds (S)-methyl-2-(4-R-phenylsulfonamido)-3-(1H-indol-3-yl)propanoate (R = H (1), Cl (2)) have been synthesized and their crystal structures also have been determined by X-ray single-crystal diffraction. Compound 1 (C18H18N2O4S) belongs to orthorhombic, space group P2(1)2(1)2(1) with a = 9.6348(14), b = 11.1517(17), c = 16.412(3) angstrom, V = 1763.4(5) angstrom 3, M-r = 358.40, Z = 4, D-c = 1.350 g/cm(3), mu = 0.209 mm(-1), F(000) = 752, R = 0.0348 and wR = 0.0714. Compound 2 (C18H17ClN2O4S) crystallizes in orthorhombic, space group P2(1)2(1)2(1) with a = 9.3128(14), b = 10.9655(16), c = 17.783(3) angstrom, V = 1815.9(5) angstrom(3), M-r = 392.85, Z = 4, D-c = 1.437 g/cm(3), mu = 0.352 mm(-1); F(000) = 816, R = 0.0389 and wR = 0.0845. The absolute structure Flack parameters X of compounds 1 and 2 are -0.03(8) and -0.06(7), respectively. X-ray analysis reveals that the crystal structures of these two compounds both involve two intermolecular N-H center dot center dot center dot O hydrogen bonds.