A Green Process Peg-600 Mediated On-Pot, Alternative Synthesis Of 3-Methyl-2-(((1-Methyl-1h-Benzimidazole-2-Yl) Sulfonyl) Methyl) Quinazolin-4(3h)-One

Condensation of 2-((1H-benzo[d]imidazol-2-yl)thio)acetic acid (1) with anthranilamide (2) in PEG-600 (polyethylene glycol), at 100 C-o for 3hr. gave 2-(((1H-benzo[d]imidazol-2-yl)thio)methyl)quinazolin-4(3H)-one (3). Treatment of 3 with DMS, DES and Ph-CH2-Cl, individually in PEG-600, at RT for 1 hr. without using any base, followed by easy process resulted in 4 (a-c). The later on reaction with H2O2 in PEG-600, for 3 hr, without using any base, followed by simple processing resulted in 5 (a-c). Alternatively, 5 (a-c) the sequence of reactions could be prepared by tandem procedure with good yields. Thus novel quinazolinone products have been prepared with new synthetic routes and strategies by using PEG-600 as solvent, in polyethylene glycol (PEG-600) in four routes. i.e. (tandem-1, tandem-2, stepwise-1 and stepwise-2) Probably, this is the first case of four variable but identical end-products- giving tandem syntheses, under green conditions, of 5 (a-c). Obviously, as figures pointed out, tandem-1 route gave good yields compared to the stepwise routes. In this process PEG-600 recycled and reused.