Lack Of Association Between Mmp-8 Polymorphisms And Osteoarthritis Susceptibility In Chinese Han Population

Research has showed that the expression of MMP-8 was upregulated in osteoarthritis cartilage than in healthy controls. And one study has described that MMP-8 polymorphisms might associated with decreased risk of osteoarthritis in a Finnish population. Thus, we analyzed whether these variants also contribute to osteoarthritis susceptibility in a Chinese Han population. Sequenom MassARRAY Assay was used to determine the genotype of 300 osteoarthritis patients and 428 healthy controls from Northwest China. Fisher's exact test/Chi-square test was used to compare the differences of the investigated SNPs (rs3740938, rs2012390, rs1940475, and rs11225395) allele and genotype distribution between osteoarthritis cases and controls. After that, the correlation between each SNP and osteoarthritis risk was assessed under multiple genetic models analysis and haplotype analysis. No significant difference was observed for the allele and genotype distribution of the four SNPs between cases and controls. Analysis of the genetic models and haplotype block also failed to reveal any significant association (P>0.05). Our present case-control study is the first to explore the potential correlation between MMP-8 polymorphisms and osteoarthritis risk in a Chinese Han population. Though, negative results we got, further study is still required to validate the potential association in other populations and a larger sample size.