Novel Therapies In Lupus Nephritis Associated With Regulatory T Cells

Lupus nephritis is a major clinical manifestation of systemic lupus erythematosus. Corticosteroids and cytotoxic agents are standard of care for lupus nephritis treatment, but are associated with considerable morbidity and suboptimal outcomes. Recently, growing evidence confirmed that regulatory T cells exert a protective effect in lupus nephritis. Drugs development targeting the regulatory T cells would be helpful in providing novel therapeutic strategies for lupus nephritis. In this review, we will discuss the relationship between lupus nephritis and regulatory T cells and introduce some novel agents acted on regulatory T cells directly or indirectly.