Clinical Research On Postoperative Analgesia Effect Of Using Dezocine Before Suturing Skin In Patients With Internal Fixation Of Spine

Objective: To discuss the effect of using different doses of dezocine before suturing skin on the postoperative pain of patients, and to evaluate the analgesia effect and the optimal dose of dezocine in inter-fixation of spine. Methods: 80 cases of patients underwent inter-fixation of spine were selected and randomly divided into four groups (n = 20): Group D1 (dezocine 0.1 mg/kg), Group D2 (dezocine 0.15 mg/kg), Group D3 (dezocine 0.20 mg/kg) and control group (Group C) (normal saline 5 ml). Group D1, D2 and D3 were intravenously injected of different dosage of dezocine 5 min before suturing skin, while Group C were intravenously injected with 5 ml saline, The four groups used postoperative sufentanil PCIA for analgesia. We observed and recorded blood pressure (BP), heart rate (HR), respiratory rate (RR) and pulse oxygen saturation of patients at entering PACU (T0), extubation (T1), 2 min post-extubation (T2), 5 min post-extubation (T3) and 10 min post-extubation (T4). In addition, we also recorded surgery time, wake up time, extubation time, cough score, agitation score, Ramsay score and postoperative VAS score, postoperative sufentanil dosage and adverse reactions of four groups of patients. Results: (1) The VAS scores within postoperative 24 h and the postoperative Sufentanil dosage of Group D1, D2 and D3 were lower than Group C, while Group D2, D3 was lower than Group D1 (P<0.05); (2) The wake up time and extubation time of Group D1, D2 and C were shorter than Group D3, the difference were statistically significant (P<0.05); Ramsay scores in postoperative 2 h of Group D1, D2, and Group C were shorter than Group D3, and the difference were statistically significant (P<0.05). (3) The cases of dizziness and drowsiness of Group D1, D2 and Group C were less than Group D3, and the difference were statistically significant (P<0.05). Conclusions: (1) The postoperative analgesia effect of using dezocine at 5min before suturing skin is positivein inter-fixation of spine. (2) The application of dezocine in inter-fixation of spine can significantly reduce the stress reaction during wakening period, improve postoperative analgesia satisfaction and reduce postoperative sufentanil dosage. (3) The most optimal dose of dezocine is 0.15 mg/kg with least adverse reactions.