Hodgkin Lymphoma Presenting With Diffuse Liver Involvement: A Rare Case Report

Hodgkin lymphoma almost always presents with disease in nodal regions, extranodal disease can sometimes occur at lung, liver, bone marrow and so forth in about 10% of cases, and most of these cases presents with regional involvement. We report a case of Hodgkin Lymphoma in a 49-year-old female with diffuse liver involvement. She suffered from recurrent fever and compromised liver function, enhanced computed tomography and ultrasonic examination only showed enlarged liver, 18F-fluorodeoxygulcose positron emission tomography/computed tomography showed diffuse elevated standard uptake value of liver. The patient underwent percutaneous liver needle biopsies, histopathological examination revealed diffuse infiltration of inflammatory cells such as lymphocytes, histiocytes and granulocytes along with Scattered Reed-Sternberg cells, which was positive for CD15, CD30, Epstein-Barr Virus and paired box protein 5 as well as negative for CD3, CD20 and leukocyte common antigen.