Clinical Analysis Of 11 Cases With Squamous Cell Carcinoma Arising From Mature Cystic Teratoma Of The Ovary

Objectives: Due to its rarity, standard management for squamous cell carcinoma (SCC) arising from mature cystic teratoma (MCT) has not been achieved. We conducted a retrospective study to analyze the clinical characteristics, treatment and prognosis of SCC-MCT and to report our experiences with this disease. Methods: We identified 11 patients treated for primary or recurrent SCC-MCT at Zhejiang Tumor Hospital between 1995 and 2014. The patient's clinical characteristics, treatment, and prognosis were retrospectively evaluated. Results: Of the 11 cases, six patients were primary SCC-MCT and five were disease recurrence. The median age was 52 years (range 46-57 years). Mean tumor size was 10.3 cm (range, 11 +/- 4 cm). Two cases had elevated level of SCC-antigen (SCC-Ag) and 4 cases demonstrated elevated level of CA125. Of the six cases with primary SCC-MCT, one case was stage IIC, and five were stage I. Three of them received adjuvant chemotherapy. The patient with stage IIC died of disease, and the overall-survival was 8 months. Of the five cases with disease recurrence, one patient refused treatment, and the other four patients received surgical resections followed by adjuvant chemotherapy or chemoradiation. Two patients died with overall-survival of 12 and 15 months. Conclusion: The overall-survival rate in patients with stage greater than I is extremely low. Therefore, early detection and adequate staging surgery are crucial for long-term survival.