Role Of Hsp90 Interacting Molecular Chaperones On Tau And A Beta Processing In Alzheimer'S Disease

Alzheimer's disease (AD) is the most prevalent dementia and a devastating disorder. Number of cases of AD are increasing each year; currently, around 5.7 million people in USA are affected by AD. The cost of patient care is in billions of dollars and by 2050 is expected to be in trillion. Currently, there is no options available to cure this disease. The mechanism of AD progression is complex and not yet fully understood. Two major hallmarks of AD are Aggregation of Amyloid beta (A beta) and microtubule associated protein tau (tau) in the brain. Our group and several others have shown molecular chaperone proteins play key role in protein folding and limiting aggregation. Especially, highly abundant chaperone Hsp90 and its co-chaperons have been linked to affect tau and A beta processing in AD models. In this chapter, we briefly discuss the role of Hsp90 interacting chaperones in AD.