Screening Technique For Heat Shock Protein 90 Inhibitors From Natural Products

Heat shock protein 90 (Hsp90) has emerged as an important target in cancer therapy, in which case screening inhibitors targeted Hsp90 attracted special attention on anti-cancer research. Recent progress in the development of screening technique for Hsp90 inhibitors has taken place. Particular emphasis is focused on ligand fishing screening assay based on protein affinity such as fluorescent ligand fishing that serve as a screening platform show case. This context will focus on strategies to screen and validate potential Hsp90 inhibitors from natural products and the development of screening techniques that are currently applied for the discovery of bioactive compounds from complex mixtures.