Dj-1 Inhibits The Progression Of Papillary Thyroid Carcinoma By Targeting Akt Pathway

Thyroid cancer is the most frequent type of malignant tumor in the endocrine system; DJ-1 has been recognized as a key player in thyroid cancer. In this study, we sought to explore the correlation of DJ-1 expression with cell proliferation, invasion and apoptosis in papillary thyroid cancer. To investigate the roles of DJ-1 in regulating the papillary thyroid cancer, we transfected si-DJ-1 into B-CPAP and CGTH-w3 cell lines, and then we tested the cell proliferation, invasion and apoptosis in papillary thyroid cancer by RT-PCR and western blot assay. The results indicated that the proliferation rate, invasive cell number and migration ability of papillary thyroid carcinoma cells, as well as Akt in the siDJ-1 transfected group significantly decreased compared with blank group. Moreover, proteins like MMP2 and MMP9 expression, was also affected by the DJ-1 expression changes. These results proved that DJ-1 could be involved in progression of papillary thyroid carcinoma by Akt signaling pathways. This study revealed the key roles of DJ-1 and its potential in preventing and treating papillary thyroid carcinoma.