Npa7: First-In-Class Bispecific Gc-A/Masr Activating Peptide That Enhances Cardiorenal Function And Suppresses Renin And Aldosterone In Vivo Via Subcutaneous Delivery

Shinobu Sugihara,Tomoko Ichiki,Yang Chen,Gail J. Harty, Seethalakshimi R. Iyer,Shuchong Pan,S. J. Sangaralingham,Daniel J. Mccormick,John C. Burnett

CIRCULATION（2018）

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摘要

Introduction: Bispecific drugs have emerged as highly efficacious medicines as they are designed to target two separate signaling pathways. We engineered a bispecific peptide NPA7 to co-activate th...

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