Prostate Gland

This chapter provides a practical overview of frequently used markers in the diagnosis and differential diagnosis of both common and rare neoplasms of prostate gland with a specific focus on adenocarcinoma and its mimickers. The chapter contains 41 questions; each question is addressed with a table, concise note, and representative pictures if applicable. In addition to the literature review, the authors have included their own experience and tested numerous antibodies reported in the literature. The most effective diagnostic panels of antibodies have been recommended for many entities, such as CK7, PAX2, and MUC6 being suggested as the best diagnostic panel for distinguishing seminal vesicles from prostatic ductal adenocarcinoma and high-grade prostatic intraepithelial neoplasia. Furthermore, immunophenotypes of normal prostate and seminal vesicles have been described, which tend to be neglected in the literature.