Oncocytic Carcinoma Of The Right Nasal Side Lacrimal Apparatus With Androgen Receptor Positive

Oncocytic carcinoma (OC) is a rare salivary gland malignant tumor without effective treatment method till now. We reported a 53-year-old man with tumor in the right eye with visual acuity 0.3. The serum of prostatic-specific antigen (PSA) was 13.2 ug/L. The tumor was resection. Microscopically, the lesion consisted of large atypical and pleomorphism epithelial tumor cells with fine, granular, esoinophilic cytoplasm composed of sheets, islands and nests with abortive glandular structures. Some cells were obviously mimicked prostate carcinoma. Immunohistochemically, the tumor cells were positive for AR, cytokeratin (AE1/AE3), CK18, CK19, alpha-1-antitripsin and negative for P504s, PSA, synaptophysin, chromogranin, and HMB-45. The pathological diagnosis was oncocytoma carcinoma of the right orbit. The prostatic was had no carcinoma with fine needle aspiration biopsy. The patient had radiotherapy and recurred in the 5 months after the first surgery. The patient died after the second surgery in the 6th month. There were some tumors with AR positive and androgen deprivation therapy were effect for them. We do not know that if all the OC were positive for AR and the androgen deprivation therapy was effective.