In vivo characterization of human disease models based on adult zebrafish with optical coherence tomography

Because of its similar genetic makeup with humans, zebrafish are an available and well-established human disease model in vivo for various human diseases as well as the drug safety-evaluation process. However, few optical imaging methods could effectively visualize the structure of adult zebrafish due to their limited penetration depth. In this paper, in vivo high-resolution and long-term characterization of various kinds of human disease models based on zebrafish were achieved with optical coherence tomography (OCT). The capability of three-dimensional OCT imaging was also played important role in visualization of zebrafish disease model. The combination of zebrafish and OCT demonstrated gratifying results in vivo characterization of human disease models based on adult zebrafish with optical coherence tomography.