Anhydrous nanoprecipitation for the preparation of nanodispersions of tenofovir disoproxil fumarate in oils as candidate long-acting injectable depot formulations

James J. Hobson,Paul Curley,Alison C. Savage,Amer Al-khouja,Marco Siccardi,Charles Flexner,Caren Freel Meyers,Andrew Owen,Steve P. Rannard

NANOSCALE ADVANCES（2019）

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摘要

The facile formation of drug nanoparticles in injectable/ingestible oils, of water-soluble antiretroviral tenofovir disoproxil fumarate, using a novel nanoprecipitation is presented with studies showing drug release into relevant aqueous media.

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